Archive for the ‘Mesothelioma’ Category

How Great the Risk of Lung Cancer by Smoking?

Thursday, September 2nd, 2010

lung cancer500

In the Netherlands, in 1948 reported a possible link between smoking and lung cancer. This was followed soon other scientific evidence that smoking can cause cancers. Especially the deceased Sir Richard Doll in 2005 from England has pioneered. Doll was the first to devastating relationship between smoking and cancer scientifically proven.

Smoking causes lung cancer. Of all people with lung cancer is nearly 90% of cases directly attributable to smoking. In 9323 deceased people to lung cancer in 2004, with 8033 times smoking was the cause. Scientists have calculated that one in seven smokers (early) dies from lung cancer.

Lung cancer in nonsmokers is not often. How great the risk of lung cancer by smoking, depending on how long and how much is smoked. There is a clear dose-response relationship. The most effective way to prevent lung cancer is not smoking.

Because passive smoking to lung cancer can also cause non-smokers are recommended to minimize the tobacco smoke of others to breathe.

Numbers
Since 1950 the Netherlands has almost 300,000 deceased from lung cancer. The majority were men. The number of men who get lung cancer in recent years become less and less. This contrasts with the dramatic increase in female lung cancer patients since the early eighties is observed. This increase is largely due to the increased number of women since the fifties has become smokers.

Smoking and other cancers
Besides lung cancer has shown a relationship between smoking and some other cancers. These are:

* Cancer of the mouth or pharynx
* Esophageal cancer
* Stomach cancer
* Pancreatic cancer
* Liver cancer
* Kidney
* Bladder Cancer
* Cervical Cancer
* Acute myeloid leukemia

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The Benign and Malignant Mesotheliomas Can Not Be Differentiated Using Criteria Histology

Monday, July 26th, 2010

HISTOLOGY

This tumor can affect the membrane covering the lung, heart or abdominal organs. [55] These tumors can spread on the surface of organs without invading deep into the underlying tissue and can spread to regional lymph nodes or distant. Mesothelioma may develop after successful treatment of an earlier cancer, especially after radiotherapy. [56,57] In adults, these tumors have been associated with exposure to asbestos, which was used as insulation in construction. [ 58] The extent of exposure required to develop cancer and there is no information about children exposed to asbestos.

The benign and malignant mesotheliomas can not be differentiated using criteria histology. Diffuse lesions and invasive and recurrent associated with poor prognosis. In general, the course of the disease is slow and long-term survival is common. Treatment with various chemotherapeutic agents used for carcinoma and sarcoma may result in a partial response. Although pain is a rare symptom, can be used with palliative radiotherapy.

Serous papillary carcinoma of the peritoneum is sometimes misidentified as mesothelioma. [59] This tumor usually affects all surfaces lining the abdominal organs, including the surfaces of the ovaries. Treatment consists of surgical resection whenever possible, and chemotherapy with agents such as cisplatin, carboplatin and paclitaxel. Refer to the PDQ summary on the treatment of malignant mesothelioma in adults for more information.

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Benign Mesothelioma

Tuesday, July 20th, 2010

umbilical-fig2

This benign epithelial neoplasm, sometimes called benign mesothelioma, is a local tumor growth is usually attached by a particle to the pleural surface.

It may be a small tumor (1 to 2cm) or can be significantly larger, but still remains confined to the surface of the lung. These tumors often produce curiously pleural effusion.

Macroscopically are trained by dense fibrous tissue with a viscous fluid-filled cyst. The tumor cells immunologically positive for CD34 and negative cells for keratin, and these features can be useful for differentiating these lesions from malignant mesothelioma. Benign fibrous tumor is not related to asbestos exposure and malignant tumors.

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Malignant Mesothelioma Treatment

Friday, July 2nd, 2010

mesothelioma-treatment-2

Malignant Mesothelioma Treatment
There are treatments for all patients with malignant mesothelioma. Uses three kinds of treatment:

* Surgery (taking out the cancer)

* Radiation therapy (using high doses of X-rays or other high-energy rays

to kill cancer cells)

* Chemotherapy (using drugs to fight cancer)

Surgery is a common treatment for malignant mesothelioma. The doctor may remove part of the lining of the chest or abdomen and some of the tissue lying around. Depending on how far the cancer has spread, you can also remove a lung in an operation called a pneumonectomy. Sometimes it also removes some of the muscle beneath the lungs that helps breathing (the diaphragm).

Radiation therapy using high energy X-rays to kill cancer cells and shrink tumors. Radiation may come from a machine outside the body (external radiation therapy) or from putting materials that C (radioisotopes) and applied to the area where cancer cells are found through thin plastic tubes (internal radiation therapy).

If fluid has accumulated in the chest or abdomen, the doctor may drain the body by inserting a needle into the chest or abdomen and pulling with gentle suction. If fluid is removed from the chest, a procedure called thoracentesis, whereas if the procedure is performed in the abdomen is called paracentesis. The doctor may also put drugs into the chest through a tube to prevent the accumulation of extra fluid.

Chemotherapy involves using drugs to kill cancer cells. These can be taken orally or injected into a vein or muscle. Chemotherapy is a systemic treatment because the drug enters the bloodstream, travels through the body and can kill cancer cells throughout the body. In the case of mesothelioma, a drug may be administered directly into the chest (intrapleural chemotherapy).

Intraoperative photodynamic therapy is a new type of treatment that uses special drugs and light to kill cancer cells during surgery. To do this, is injected into a vein a drug that makes cancer cells more sensitive to light several days before surgery. During surgery to remove as much cancer as possible, a special light is used to illuminate the pleura. This treatment is being studied for early stages of mesothelioma in the chest.

Treatment by stage
Treatment depends on where the cancer is, how the disease has spread, your age and health status in general.

You might consider a treatment that is considered standard based on their effectiveness in a number of patients in past studies, or may choose to take part in a clinical trial. Not all patients are cured with standard therapy and some standard treatments may have more side effects than are desired. For these reasons, clinical trials are designed to find better ways to treat cancer patients and are based on the most current information. Are conducting clinical trials in various parts of the country for many patients with malignant mesothelioma.

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Treatment

Monday, June 28th, 2010

TreatmentChemotherapy:

The adjuvant chemotherapy should be administered 4-6 weeks after surgery and be continued por4 to 6 cycles. The most commonly used chemotherapeutic agents are doxorubicin (50-90mg/m2) for 4 weeks and mitomycin, who has lung toxicity in 12 mg/m2 for the same amount of time.

Combinations with other drugs increase the effect slightly. But given chemotherapy than those named, has no meaning for the little effect of the same in this condition.

Studies have shown that administration of chemotherapeutic agents in the pleural space, had better outcome than administered systemically. However, this scheme leaves out the protocol and should be considered better.

Radiation:

Malignant mesothelioma is a moderately radiosensitive tumor. But we must radiate throughout the hemithorax, which produce severe toxicity. (more…)

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Mesothelioma Lung

Friday, June 25th, 2010

Mesothelioma LungTREATMENT.

The standard treatment for all cases of mesothelioma with the exception of localized mesothelioma is generally not curative. Although some patients experience long-term survival with aggressive treatment, it remains unclear if overall survival has been significantly altered by the different treatment modalities or by combinations of modalities.

Extrapleural pneumonectomy in selected patients with early stage disease can get a recurrence-free survival, but its impact on overall survival is unknown. Pleurectomy and decortication can provide palliative relief from symptomatic effusions, discomfort caused by tumor burden and pain caused by tumor invasion.

The addition of radiotherapy and chemotherapy after surgery has not demonstrated improved survival. Using radiation therapy in pleural mesothelioma has proven pain relief in most patients. However, the duration of symptom control is short. Single agent chemotherapy and combination chemotherapy have been assessed in (more…)

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Causes, treatment and prevention of mesothelioma asbestosis

Tuesday, June 22nd, 2010

mesothelioma asbestosis Mesothelioma Asbestosis is a lung disease such as work-related cancer mesothelioma. Affects the parenchyma of the lung tissue. During exposure to asbestos is the reason behind the disease. Here the parenchyma tissue pain and irritable remain permanently as a result of which dyspnea or shortness of breath occur. There is a greater chance of developing lung cancer as well. In this case, the plate is formed above the diaphragm due to over exposure to asbestos. This was evident in the X-ray tests.

difficulty breathing is the primary symptom of mesothelioma and asbestosis people who are severely infected may become victims of total respiratory failure. Usually it takes more than ten years before the disease occurs after exposure to asbestos. At the same time acknowledged that the cases are where the disease began with three months notice. There are two main types of asbestos particles, namely, amphibole and serpentine. Amphibole is thin and straight, while serpentine is curved. The amphiboles are responsible for asbestosis, as they can gain insight into the lungs by inhalation and damage the lung tissue around terminal bronchioles and alveolar ducts. (more…)

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Treatment Options for Mesothelioma – drugs

Saturday, June 19th, 2010

Treatment Options for Mesothelioma - drugs The Traditional Chemotherapy

This traditional approach uses special carcinogenic drugs (cytotoxins) and chemists to try to kill malignant cells. Often this therapy is offered as an additional therapy alongside radical surgery and / or in combination with radiation therapy or immunotherapy, particularly when the cancer has spread beyond an area opearble. It has been tested against malignant mesothelioma with many drugs, but has had limited success with everyone.

You can administer the chemotherapeutic agents or systemic (in the blood stream) or intrapleuramente (within the pleural cavity itself.) These cytotoxic drugs are very potent and can cause severe side effects. You should talk to your doctor, smiling these side effects.

Additional Resources: (more…)

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Mesothelioma Treatment

Tuesday, June 1st, 2010

Mesothelioma Treatment The best treatment option for you depends on many factors, including age, general health status, cancer stage, cell type (which determines the aggressiveness of the cancer) and most importantly, your personal desires. To help you evaluate these options, will have a “multidisciplinary team (MDT) of physicians who will discuss your case and afford the best treatment option. Members of this team may include a cardiothoracic surgeon, a medical oncologist, a radiation oncologist, a specialist in pain (more…)

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Cancer

Monday, May 31st, 2010

Cancer Malignant Mesothelioma Treatment

There are treatments for all patients with malignant mesothelioma. Uses three types of treatments:

* Surgery (taking out the cancer).
* Radiation therapy (using high doses of X-rays or other high-energy rays to kill cancer cells).
* Chemotherapy (using drugs to fight cancer).

Surgery is a common treatment for malignant mesothelioma. The doctor may remove part of the lining of the chest or abdomen and some of the tissue lying around. Depending on how far the cancer has spread, you can also remove a lung in an operation called a pneumonectomy. Sometimes it also removes some of the muscle beneath the lungs that helps breathing (the diaphragm).

Radiation therapy using high energy X-rays to kill cancer cells and shrink tumors. Radiation may come from (more…)

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