Archive for the ‘Asbestos’ Category

Pleural Plaques are Precursors of Malignant Mesothelioma

Thursday, July 29th, 2010

ASBES

Asbestos is a term that includes a number of magnesium and iron silicates, fibrous, very complex, with different chemical composition and morphology. The three most important types are: chrysotile (Mg 3 Si 2 O 5 (OH 4), white asbestos), crocidolite (Na 2 Fe +2 Fe +3 (OH / Si 4 O 11) 2, blue asbestos) and amosite ( brown asbestos). The first is the upper airway and the other two reach the lung periphery. Asbestosis is then for a silicatosis.

Exposure to asbestos can cause: fibrous pleural plaques, asbestosis and malignant mesothelioma of the pleura and peritoneum.

Emphysema

Pleural fibrous plaques: Unlike the fibrous thickening of the visceral pleura accompanying asbestosis, the plates are located in the parietal pleura, postero-lateral areas, mainly on the ribs and diaphragm, are bilateral, well defined, irregular, whitish and upraised. The surface can be nodular or smooth, simulate articular cartilage. Histological, collagen lamellae consist of hyaline and sparsely cellular. There may be extensive foci’s of calcification. The so-called ferruginous bodies or asbestos bodies are not found in large quantities in the plates, but in the lung itself. Currently there is evidence to support the idea that pleural plaques are precursors of malignant mesothelioma.

Asbestosis: mean pulmonary fibrosis by inhalation of asbestos dust. All types of asbestos above can produce, to varying degrees. The most important is the concentration and exposure time. The shorter fibers (10 mm or less) are phagocytosed or surrounded by macrophages forming granulomas. The largest, both favor the precipitation of endogenous protein and iron and leave the fiber as the core and forming the so-called ferruginous bodies or asbestos bodies. These structures are thin, elongated cane, yellow copper, up to 50 um long. The proteinaceous shell is usually segmented and the ends are bulbous. The finding of asbestos bodies in lung or sputum indicates exposure, not only is evidence of asbestos disease. These bodies have been found in people of the metropolis, not exposed, up to 60% of autopsies.

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Knowledge of Risk From the Asbestos Industry

Friday, May 14th, 2010

the Asbestos Industry

For decades, manufacturers of products containing asbestos and many of the companies that employ men and women who work with these products, have knowingly exposed workers to risks such harmful. The attitude of these companies is demonstrated by the testimony of Charles H. Roemer, a former employee of Unarco, who describes a meeting between officers from Unarco and Lewis Brown, president of Johns-Manville and his brother, Vandiver Brown, in the early ’40s:

“I’ll never forget, one of Brown said Unarco managers were fools for notifying employees who had asbestosis, and I said, ‘Mr. Brown “you are telling me they prefer their employees to work until they drop dead?” He said, ‘Yes We save much money that way. ‘ “1

That attitude is reflected again and again through the decades, thousands of industry documents. Companies that manufacture and use asbestos products had extensive information that showed them and confirmed the dangers of harmful material. Scientific publications, medical literature, industry organizations, and in many cases, their own internal reports, studies and other documents.

The amount of documents produced and held by the asbestos industry has a common theme: indisputable evidence that exposure to asbestos is harmful and causes death in people exposed to the fiber. This information could have prevented many deaths related to asbestos, if the information had been used to protect workers and the public.

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Asbestos: A Historical Overview

Thursday, May 13th, 2010

Asbestos

The term “asbestos” originated from Greek, meaning “indestructible”. The term is commonly used to refer to the group of mineral fibers that share properties of thermal and chemical resistance, flexibility and high tensile strength. Because of its many uses, asbestos is also known as “the magic mineral” and is incorporated in more than 3,000 products used in industry or at home.

Although asbestos was used in many products during the industrial revolution (and still used today) modern industry was not the first to use this material as harmful. The use of asbestos beyond the year 2500 BC, when used in the manufacture of pottery Finnish. One of the earliest uses of asbestos was its use in the wick of a lamp of gold to the goddess Athena created between the fourth and fifth centuries BC. During that period Asbestos blankets were used to hold the ashes of the dead during cremation and Pliny describes the use of asbestos cloth as the funeral dress of kings. In an act of exhibitionism, it is said that Charlemagne showed an asbestos tablecloth in the great hall. After the feast, the cloth and its contents are fire and threw it back out intact to the amazement of the guests. Also, during his travels in 1240, Marco Polo was referring to a fabric in the northern provinces of the Great Khan who had the property not be consumed and purified with fire.

Industrial use of asbestos began on a moderate scale, following the discovery of a substantial deposits of asbestos in the Ural mountains in western Russia, around 1720. The discovery led to the founding of the first factory of asbestos products, including textiles, socks, gloves and handbags. Then came more discoveries of different types of asbestos in different continents and therefore their use in many applications.

Chrysotile asbestos was discovered in Quebec, Canada in 1860 and extraction began in 1878 when there were 50 tonnes in the first year of operations. Then crocidolite asbestos was discovered in South Africa in 1815 and substantial exploitation began around 1910 fibers. Amosite asbestos was discovered in the central Transvaal in 1907 and mining operations and began operating in 1916. The institution of these operations, along with the industrial revolution, defined the widespread use of asbestos and the public health crisis that would result.

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Asbestos Product: Risk of developing mesothelioma

Monday, May 10th, 2010

asbestos

Who is at risk for developing mesothelioma?
Those who have worked directly with asbestos or asbestos products are most at risk of developing mesothelioma, but have found some cases of mesothelioma in people with minimal exposure.

The professions that have a high risk of developing mesothelioma include:
* Workers with metal plates (including shipbuilding)
* Manufacturers of vehicle bodies (including rail vehicles)
* Plumbers
* Gas Technicians
* Carpenters
* Electricians
* Construction workers
* Plasterer
* Constructors
* “Manitas”
* Steel Installers
* Painting
* Sheet metal workers
* Welders

(more…)

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Protein HLJ1

Monday, April 19th, 2010

Protein HLJ1 Protein HLJ1 is involved in slowing the progression of lung cancer, the researchers said.
Scientists at the National Taiwan University (China) have concluded that a protein called HLJ1 could function as tumor suppressor in non-small cell lung cancer.

The study, which publishes the Journal of the National Cancer Institute was based on increasing or blocking HLJ1 expression in lung carcinoma cells, and gene expression observed in tumors and adjacent tissue cells in 71 patients with cancer NSCLC.

The scientists found that, by stopping the proliferation of cancer cells HLJ1 lung, slowed the progression of cell division cycle and inhibited the ability of cells to move and invade other tissues. In addition, they found that patients with tumors that produced higher amounts of HLJ1 tended to lower cancer recurrence and a longer life than those whose tumors had lower protein presence.

In conclusion, the researchers say that this protein is a novel tumor suppressor of this type of lung cancer, which would benefit those who suffer from a complementary therapy and facilitate the design of individualized treatments. (more…)

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Risk Factors OF Colorectal Cancers

Saturday, April 10th, 2010

 Colorectal Cancers And Risk Factors  The risk is even stronger there are more people living in the family, this case are close (father, mother, brother, sister), and that this case are young .
* Age: rare for fifty years, colorectal cancers are becoming quite common about 65 years.
* Heredity or mutations: the risk of colorectal cancer is higher if a relative has a colorectal cancers.

It has identified high-risk families, where people have a specific mutation that predisposes to cancer. These families represent only that 5% of colorectal cancers:
No familial adenomatous polyposis (FAP) where numerous polyps appear in all carriers of mutated APC gene. In adulthood, one of these polyps inevitably (more…)

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Asbestos Prediction

Wednesday, March 31st, 2010

asbestosAsbestos causes cancer. It is a mineral that occurs in white fibers and flexible, silky finish. It is a silicate of lime, alumina and iron, and with it has been made fireproof fabrics.

Also known as asbestos, asbestos was used for many products, such as construction materials (tiles, slabs and tiles, paper products and cement), auto clutch, brakes, heat-resistant textile materials, containers, packaging and coatings personal protective equipment, paintings, is also present in some foods. However, international medical organizations have shown that asbestos-containing products cause cancer. Thus, for decades was banned in all developed countries, but is still used in some developing. (more…)

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Asbestos And Mesothelioma Mortality

Monday, March 29th, 2010

asbestosLast May Saturnino Platas died from cancer of the pleura, caused by contact with asbestos during the eight years I have worked in the company Fibrocement (Alicante). For this same reason the historic leader died CCOO, Manuel Deus Amor (Ferrol) only a month later. Estimates are that about 1321 deaths occur from mesothelioma between 2007 and 2016.

At present there is little doubt about the relationship between exposure to asbestos and diseases such as pleural mesothelioma. However, the number of cases recognized in Spain by Social Security is far from reality: 6 cases in 2003 and 5 in 2005. This even though they are already several autonomous communities that have implemented monitoring programs of the past have suffered health of workers exposed to asbestos in order to promote recognition of these diseases and their compensation as occupational diseases. A program that is mandatory but has not yet been developed in some Autonomous Communities, having left go years without doing anything. (more…)

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Asbestos Exposure

Tuesday, March 23rd, 2010

Direct exposure to asbestos

mesotheliomaThe risks of developing mesothelioma increase with the intensity and duration of asbestos exposure. Most persons who develop mesothelioma were directly exposed to asbestos at their jobs for long periods of time. Following are a list of some of the higher risk jobs occupations:

Auto Mechanics – at risk of developing mesothelioma because brake pads and clutches contained asbestos
Boiler makers – at risk of developing mesothelioma because asbestos insulation was wrapped around the boilers
Bricklayers - at risk of developing mesothelioma because certain bricks, most notably firebricks, contained asbestos
Building Inspectors - at risk of developing mesothelioma from regular exposure to construction sites containing asbestos
Carpenters – at risk of developing mesothelioma because flooring, roofing, insulation, and joint compound contained asbestos
Drywallers – at risk of developing mesothelioma because joint compound contained asbestos
Electricians – at risk of developing mesothelioma because electrical wiring coverings contained asbestos and because often were required to cut insulation to do work (more…)

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Mesothelioma Causes Death

Monday, March 15th, 2010

Malignant MesotheliomaMesothelioma is a cancer that results from a genetic mutation within the cells of the body. The mutation causes healthy cells to change into malignant cells (cells that grow uncontrollably). These out-of-control cells multiply rapidly, forming tumors that interfere with the body’s functions; the tumors in turn spread more malignant cells through the entire body. In time, mesothelioma causes death. Mesothelioma is a cancer that results from a genetic mutation within the cells of the body. The mutation causes healthy cells to change into malignant cells (cells that grow uncontrollably).

These out-of-control cells multiply rapidly, forming tumors that interfere with the body’s functions; the tumors in turn spread more malignant cells through the entire body. In time, mesothelioma causes death.

Mesothelioma appears in a variety of forms, and no universal cause of mesothelioma has been discovered. Researchers have discovered that health, lifestyle, and the environment play a significant role in the development of disease; however, the primary cause of mesothelioma in most people is exposure to asbestos.

Asbestos is a fibrous mineral known for its durability, ease of extraction and processing, and its high resistance to heat, flame, and electric currents. It comes in many forms, including woven material, and is found in many products – especially in the manufacturing, resource extraction and processing, and home construction industries. (more…)

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